Product Details

Shanghai Up-Fluorochem Co., Ltd. offers Remdesivir intermediates 2,3,5-Tri-O-benzyl-D-ribonolactone (CAS No. 55094-52-5) for your requirements of R&D, evaluation, pilots and commercial along with supportive technical package required for evaluation

Remdesivir, also known as GS-5734, is a novel antiviral drug in the class of nucleotide analogs developed by Gilead Sciences. In February 2020 Remdesivir was being studied for experimental treatment of the emergent COVID-19 (novel coronavirus) disease.

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Contact: Mr. Zou

Email: info@upfluorochem.com

SDS

SAFETY DATA SHEETS

According to the UN GHS revision 8

SDS Version: 1.0

Creation Date: Apr. 16, 2020

Revision Date: Apr. 16, 2020




1.Identification

1.1GHS Product identifier

Product name	2,3,5-Tri-O-benzyl-D-ribonolactone

1.2Other means of identification

Product number	-
Other names	(3R,4R,5R)-3,4-bis(phenylmethoxy)-5-(phenylmethoxymethyl)oxolan-2-one;

1.3Recommended use of the chemical and restrictions on use

Identified uses	Intermediate of the anti-covid-19 drug remdesivir
Uses advised against	no data available

1.4Supplier's details

Company	Shanghai Up-Fluorochem Co., Ltd.
Address	T2-1623, Zhonggeng Global Creative Center, Lane 166, Minhong Road, Minhang District, Shanghai, China, 202155
Telephone	+86-18721967067
Fax	-

1.5Emergency phone number

Emergency phone number	Local Fire/Emergency Telephone Number
Service hours	Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

2.Hazard identification

2.1Classification of the substance or mixture

no data available

2.2GHS label elements, including precautionary statements

Pictogram(s)	no data available
Signal word	no data available
Hazard statement(s)	no data available
Precautionary statement(s)
Prevention	no data available
Response	no data available
Storage	no data available
Disposal	no data available

2.3Other hazards which do not result in classification

no data available

3.Composition/information on ingredients

3.1Substances

Chemical name	Common names and synonyms	CAS number	EC number	Concentration
(3R,4R,5R)-3,4-Bis(benzyloxy)-5-((benzyloxy)methyl)dihydrofuran-2(3H)-one	2,3,5-Tri-O-benzyl-D-ribonolactone	55094-52-5	-	>99%

4.First-aid measures

4.1Description of necessary first-aid measures

General advice

Medical attention is required. Consult a doctor. Show this safety data sheet (SDS) to the doctor in attendance.

If inhaled

Move the victim into fresh air. If breathing is difficult, give oxygen. If not breathing, give artificial respiration and consult a doctor immediately. Do not use mouth to mouth resuscitation if the victim ingested or inhaled the chemical.

Following skin contact

Take off contaminated clothing immediately. Wash off with soap and plenty of water. Consult a doctor.

Following eye contact

Rinse with pure water for at least 15 minutes. Consult a doctor.

Following ingestion

Rinse mouth with water. Do not induce vomiting. Never give anything by mouth to an unconscious person. Call a doctor or Poison Control Center immediately.

4.2Most important symptoms/effects, acute and delayed

no data available

4.3Indication of immediate medical attention and special treatment needed, if necessary

no data available

5.Fire-fighting measures

5.1Extinguishing media

Suitable extinguishing media

Use dry chemical, carbon dioxide or alcohol-resistant foam.

5.2Specific hazards arising from the chemical

no data available

5.3Special protective actions for fire-fighters

Wear self-contained breathing apparatus for firefighting if necessary.

6.Accidental release measures

6.1Personal precautions, protective equipment and emergency procedures

Avoid dust formation. Avoid breathing mist, gas or vapours. Avoid contacting with skin and eye. Use personal protective equipment. Wear chemical impermeable gloves. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Keep people away from and upwind of spill/leak.

6.2Environmental precautions

Prevent further spillage or leakage if it is safe to do so. Do not let the chemical enter drains. Discharge into the environment must be avoided.

6.3Methods and materials for containment and cleaning up

Collect and arrange disposal. Keep the chemical in suitable and closed containers for disposal. Remove all sources of ignition. Use spark-proof tools and explosion-proof equipment. Adhered or collected material should be promptly disposed of, in accordance with appropriate laws and regulations.

7.Handling and storage

7.1Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

7.2Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

8.Exposure controls/personal protection

8.1Control parameters

Occupational Exposure limit values

no data available

8.2Appropriate engineering controls

Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.

8.3Individual protection measures, such as personal protective equipment (PPE)

Eye/face protection

Wear tightly fitting safety goggles with side-shields conforming to EN 166(EU) or NIOSH (US).

Skin protection

Wear fire/flame resistant and impervious clothing. Handle with gloves. Gloves must be inspected prior to use. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

Respiratory protection

If the exposure limits are exceeded, irritation or other symptoms are experienced, use a full-face respirator.

Thermal hazards

no data available

9.Physical and chemical properties

Physical state	no data available
Colour	no data available
Odour	no data available
Melting point/ freezing point	no data available
Boiling point or initial boiling point and boiling range	no data available
Flammability	no data available
Lower and upper explosion limit / flammability limit	no data available
Flash point	no data available
Auto-ignition temperature	no data available
Decomposition temperature	no data available
pH	no data available
Kinematic viscosity	no data available
Solubility	no data available
Partition coefficient n-octanol/water	no data available
Vapour pressure	no data available
Density and/or relative density	no data available
Relative vapour density	no data available
Particle characteristics	no data available

10.Stability and reactivity

10.1Reactivity

no data available

10.2Chemical stability

no data available

10.3Possibility of hazardous reactions

no data available

10.4Conditions to avoid

no data available

10.5Incompatible materials

no data available

10.6Hazardous decomposition products

no data available

11.Toxicological information

Acute toxicity

• Oral: no data available

• Inhalation: no data available

• Dermal: no data available

Skin corrosion/irritation

no data available

Serious eye damage/irritation

no data available

Respiratory or skin sensitization

no data available

Germ cell mutagenicity

no data available

Carcinogenicity

no data available

Reproductive toxicity

no data available

STOT-single exposure

no data available

STOT-repeated exposure

no data available

Aspiration hazard

no data available

12.Ecological information

12.1Toxicity

• Toxicity to fish: no data available

• Toxicity to daphnia and other aquatic invertebrates: no data available

• Toxicity to algae: no data available

• Toxicity to microorganisms: no data available

12.2Persistence and degradability

no data available

12.3Bioaccumulative potential

no data available

12.4Mobility in soil

no data available

12.5Other adverse effects

no data available

13.Disposal considerations

13.1Disposal methods

Product

The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Contaminated packaging

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

14.Transport information

14.1UN Number

ADR/RID: Not dangerous goods.

IMDG: Not dangerous goods.

IATA: Not dangerous goods.

14.2UN Proper Shipping Name

ADR/RID: Not dangerous goods.

IMDG: Not dangerous goods.

IATA: Not dangerous goods.

14.3Transport hazard class(es)

ADR/RID: Not dangerous goods.

IMDG: Not dangerous goods.

IATA: Not dangerous goods.

14.4Packing group, if applicable

ADR/RID: Not dangerous goods.

IMDG: Not dangerous goods.

IATA: Not dangerous goods.

14.5Environmental hazards

ADR/RID: No

IMDG: No

IATA: No

14.6Special precautions for user

no data available

14.7Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code

no data available

15.Regulatory information

15.1Safety, health and environmental regulations specific for the product in question

Chemical name	Common names and synonyms	CAS number	EC number
(3R,4R,5R)-3,4-Bis(benzyloxy)-5-((benzyloxy)methyl)dihydrofuran-2(3H)-one	2,3,5-Tri-O-benzyl-D-ribonolactone	55094-52-5	-
European Inventory of Existing Commercial Chemical Substances (EINECS)			Not Listed.
EC Inventory			Not Listed.
United States Toxic Substances Control Act (TSCA) Inventory			Not Listed.
China Catalog of Hazardous chemicals 2015			Not Listed.
New Zealand Inventory of Chemicals (NZIoC)			Not Listed.
Philippines Inventory of Chemicals and Chemical Substances (PICCS)			Not Listed.
Vietnam National Chemical Inventory			Not Listed.
Chinese Chemical Inventory of Existing Chemical Substances (China IECSC)			Not Listed.
Korea Existing Chemicals List (KECL)			Not Listed.

16.Other information

Information on revision

Creation Date	Apr. 16, 2020
Revision Date	Apr. 16, 2020

Abbreviations and acronyms

• CAS: Chemical Abstracts Service

• ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road

• RID: Regulation concerning the International Carriage of Dangerous Goods by Rail

• IMDG: International Maritime Dangerous Goods

• IATA: International Air Transportation Association

• TWA: Time Weighted Average

• STEL: Short term exposure limit

• LC50: Lethal Concentration 50%

• LD50: Lethal Dose 50%

• EC50: Effective Concentration 50%

References

• IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home

• HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm

• IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/

• eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en

• CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple

• ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp

• ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg

• Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp

• ECHA - European Chemicals Agency, website: https://echa.europa.eu/

Any questions regarding this SDS, Please send your inquiry to sds@xixisys.com




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Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.

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